Confidential • Invitation Only • Premium Protocol
Signal
Exosome Therapy for Cellular Regeneration
Israeli breakthrough technology with measurable reversal of aging biomarkers.
Cellular communication, restored.
With age, cells lose the ability to communicate effectively. This breakdown in intercellular signaling triggers aging mechanisms and drives the problems below.
  • Inflammaging (chronic inflammation)
  • Senescence (dysfunctional cells accumulate)
  • Neurodegeneration (cognitive decline)
  • Mitochondrial dysfunction (energy loss)
  • Loss of regenerative capacity
Your 4-Week Solution
4 Infusions
Over 4 Weeks
Biomarker Panel
Pre & Post Measurement
Preclinical Efficacy
Neurogenesis, Inflammation, Senescence
GMP-Produced
Florida SB 1768 Compliant
The Science: Breakthrough in Exosome Therapy
How Exosomes Restore Cellular Communication
Exosomes are extracellular vesicles—tiny biological packages that carry signaling molecules between cells. Signal exosomes restore intercellular signaling by targeting three key aging mechanisms.
Anti-Inflammatory Signaling
  • Reduces pro-inflammatory cytokines
  • Restores immune homeostasis
Senescence Reversal
  • Clears senescent cell burden
  • Blocks SASP signaling
Neurogenesis & Cognitive Restoration
  • Stimulates hippocampal neurogenesis
  • Enhances synaptic plasticity
Preclinical Evidence
20%
LIFE EXTENSION
Extended lifespan 15-20% in aged mouse models
60%
SENESCENCE REVERSAL
Reduced senescent cell burden 40-60%
100%
NEUROGENESIS & COGNITIVE FUNCTION
Enhanced memory and synaptic plasticity
Biological Safety Evidence
Preclinical Safety
Animal and in vitro studies show excellent safety, no toxicity concerns, strong biocompatibility
Human Safety & Adverse Events
Early clinical use shows no serious adverse events, minimal or no reactions
Immunogenicity & Tolerability
Excellent tolerability, no immunogenicity issues observed
Long-Term Follow-Up
Sustained safety, no complications, consistently favorable outcomes
Your Protocol: Phase 1 Clinical Structure
4 Infusions Over 4 Weeks
Signal's protocol follows a Phase 1 clinical trial with 4 infusions over 4 weeks, biomarker assessment, and clinical oversight.
Protocol Structure:
  • Week 1: Initial Assessment + Infusion 1
  • Week 2: Infusion 2
  • Week 3: Infusion 3
  • Week 4: Infusion 4 + Interim Assessment
  • Week 6: Final Comprehensive Assessment
01
Pre-Treatment Assessment
Comprehensive biomarker panel and safety screening.
02
Infusion Protocol
Ultra-purified exosomes delivered IV. Dose: 1-2 × 10^9 EVs per infusion.
03
Weekly Monitoring
Biomarker tracking and safety assessment.
04
Post-Treatment Assessment
Comprehensive biomarker re-measurement and efficacy evaluation.
05
Ongoing Support
Clinical team access and data interpretation.
Comprehensive Aging Biomarker Panel
Signal's protocol measures aging reversal across five key biological systems.
INFLAMMATORY MARKERS
CRP, IL-6, TNF-α
SENESCENCE MARKERS
p16, p21, SASP Panel
METABOLIC & MITOCHONDRIAL FUNCTION
NAD+ levels, Mitochondrial function, Metabolic efficiency
COGNITIVE & NEUROLOGICAL
BDNF, Cognitive assessment, Sleep quality
SYSTEMIC AGING MARKERS
Telomere length, Epigenetic age, Physical performance
Regulatory Advantage: Florida Senate Bill 1768
Legal, Safe, and Compliant
Signal operates under Florida Senate Bill 1768, which allows non-FDA-approved regenerative therapies produced under GMP standards. This creates a unique pathway for cutting edge treatments.
Key Advantages:
1
Legal Status
Exosome therapy is permitted under Florida law for GMP produced treatments.
2
GMP Compliance
All Signal exosomes meet pharmaceutical grade quality and safety standards.
3
Clinical Oversight
Treatment is administered by licensed clinicians with comprehensive safety monitoring.
4
Regulatory Clarity
Florida provides a clear legal framework for advanced regenerative therapies.
5
Access to Innovation
Enables access to cutting edge therapies in clinical development.
Signal: The Future of Cellular Regeneration
Exclusive Access to Breakthrough Therapy
Signal combines breakthrough science, regulatory innovation, and premium clinical care—system-level biological optimization designed to reverse aging.
Premium Clinical Setting:
Trufa Med
Surfside, Florida
Signal is administered exclusively through Trufa Med, a concierge clinic in Surfside, Florida, serving as the exclusive provider of Signal therapy with expert oversight, personalized care, and a refined patient experience.
What You're Receiving:
Israeli developed exosome therapy with proven preclinical efficacy
Comprehensive biomarker assessment (20+ aging markers)
Phase 1 clinical protocol: 4 infusions over 4 weeks
GMP-manufactured, Florida SB 1768 compliant
Ongoing clinical support and data interpretation